Virginia Tech®home

Nammalwar Sriranganathan, BVSc, MVSc, PhD, DACVM

Professor
  • Bacteriology
Nammalwar Sriranganathan
Department of Biomedical Sciences and Pathobiology
Center for One Health Research
VA-MD College of Veterinary Medicine
Virginia Tech
205 Duck Pond Drive
Blacksburg, VA 24061

ECFVG, 1976
American Veterinary Medical Association
Licensed to practice veterinary medicine and surgery in the states of Washington and Oregon

PhD, Molecular Biology, 1974
Oregon State University
Corvallis, Oregon

MVSc, Veterinary Microbiology, 1968
University of Agricultral Sciences
Bangalore, India

BVSc, Veterinary Medicine and Surgery, 1966
University of Agriculture Sciences
Bangalore, India

  • Diplomate, American College of Veterinary Microbiologists, 1978
  • Targeted drug delivery for intracellular pathogens
    In the last few decades, the emergence of drug resistant strains of Salmonella sp., Brucella sp., Mycobacterium sp., etc. representing intracellular bacterial pathogens is manifesting into a global health problem thereby raising new pharmaceutical challenges and necessitating the development of an efficient and cost effective novel agent. My laboratory is aiming to achieve site specific targeted drug delivery with increased bioavailability of antimicrobials/drugs using nanoparticles as carriers. Our ultimate goal is to design and develop novel nanoparticle based drugs by incorporating biological, engineering and chemical manufacturing principles for therapeutic application of chronic infectious diseases, i.e., tuberculosis, brucellosis and salmonellosis. In addition, I also believe that development of nanoparticle based targeted drug delivery system may provide new therapeutic opportunities for the use of vast array of unstable, toxic, and insoluble antimicrobials (sitting on the shelves of drug companies), with minimum or no deleterious side effects.
  • Development of vaccines against bioterrorism agents
    My main interests are in understanding the host-parasite relationships, pathogenesis, virulence and their applications in vaccine development. At present my research focuses mainly on Brucella. My research effort is geared towards generation and testing of recombinant B. abortus RB51 vaccines against Anthrax, Tuberculosis, Paratuberculosis, Rift Valley Fever and Neosporosis. Microarray development to study host/pathogen interactions.
  • Bacteriophage based remediation of food borne Salmonella in poultry
    In the last six years, I initiated research to investigate the potential of phages as remedial agents in poultry. The entire chromosomal sequence (86.165kb) of one broad host range Salmonella species-specific phage called Felix 01has been determined. This was done to explore using such long-term surviving phages as therapeutic and or bioremedial agent against drug resistant Salmonella. Exploring bioremediation processes to treat regulated medical waste.
  • Enterotoxigenic E. coli
    My early efforts were focused on the isolation, purification and characterization of Heat-Stable Enterotoxin (STa). We were the first to show that bovine enterotoxigenic E.coli (ETEC) produced an 18 amino acid peptide. We also demonstrated by amino acid sequencing that bovine STa was similar, if not identical, to an 18-19 amino-acid peptide produced by human ETEC.
  • Molecular Immunology
    Characterization and quantitation of cytokine mRNA expression in lymphocytes from mice.
  • Vaccines and aging
    Effect of aging on immune response

2003-present
Professor, Bacteriology


Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

1990-2003
Associate Professor, Bacteriology


Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

1984-1990
Assistant Professor, Bacteriology

Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

1979-1984
Assistant Professor

Washington State University
Pullman, WA

1976-1978
Postdoctoral/Research Associate

USDA
Washington, DC

1974-1975
Intern

Veterinary Clinic
Centralia, WA

1968-1970
Veterinary Surgeon

Civil Veterinary Hospital Instructor
UAS
Bangalore, India

  • American Society for Microbiology (1973-present)
  • American College of Veterinary Microbiologists (1978-present)
  • American Association of Veterinary Laboratory Diagnosticians (1979-present)
  • Conference of Research Workers in Animal Diseases (1982-present)