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                  The Comparative Oncology Research Laboratory is housed at the Animal Cancer Care and Research Center at the Roanoke Virginia Tech campus, and includes clinician scientists and researchers who embrace the One Health concept to improve cancer outcomes for veterinary and human patients.The overall goal of my research is to improve cancer outcomes for veterinary and human patients via tumor ablation and immunotherapy. Specifically, our research team investigates the use of two non-thermal tumor ablation techniques – histotripsy and high-frequency irreversible electroporation (H-FIRE). Our research focuses on developing histotripsy as a tumor ablation modality for the primary tumor in osteosarcoma, and on developing H-FIRE as a tumor ablation modality for metastatic tumors in osteosarcoma. Additionally, our research also evaluates the immune response after histotripsy and H-FIRE ablation of tumors. Our research team utilizes veterinary clinical trials, preclinical models and in-vitro systems to explore the ablative and immunomodulatory effects of histotripsy and H-FIRE.Additionally, I work in partnership with other researchers at Virginia Tech and at the Duke Cancer Institute with expertise in orthopedic and computational mechanobiology, comparative pathobiology, immunology, comparative oncology, cancer and evolutionary biology.The strength of the dog as a comparative oncology model in osteosarcoma enables our veterinary clinical trial work to inform future studies focusing on developing histotripsy for human osteosarcoma patients.
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