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William R. Huckle, MS, PhD

Associate Professor
  • Cell Biology/Pharmacology
William Huckle
Department of Biomedical Sciences and Pathobiology
VA-MD College of Veterinary Medicine
Virginia Tech
205 Duck Pond Drive
Blacksburg, VA 24061

PhD, Pharmacology, 1988
University of Iowa
Iowa City, IA

MS, Biochemistry, 1981
Virginia Tech
Blacksburg, VA

BA, Chemistry, 1978
Williams College
Williamstown, MA

  • Intracellular signaling mechanisms
  • Regulation of growth factor receptor mRNA variants
  • Maintenance and growth of blood vessels in cardiovascular disease and cancer
  • Development of vascular networks during pregnancy

1999–present
Associate Professor

Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

1992–1999
Research Fellow

Merck & Company
West Point, PA

1988–1992
Post-doctoral Fellow/Research Assistant Professor

University of North Carolina-Chapel Hill
Chapel Hill, NC

1983–1984
Staff Biochemist

GIBCO-BRL/Life Technologies
Gaithersburg, MD

  1. Huckle, W.R., and Roche, R.I. (2004) Post-transcriptional control of expression of sFlt-1, an endogenous inhibitor of vascular endothelial growth factor, J. Cell. Biochem. 93:120-132.
  2. Troy, G.C., Huckle, W.R., Rossmeisl, J.H., Panciera, D., Lanz, O., Robertson, J.L., Ward, D.L. (2006) Endostatin and vascular endothelial growth factor concentrations in healthy dogs and dogs with selected neoplasias, J. Vet. Int. Med. 20:144-150.
  3. MacLean, H.N., J.A. Abbott, D.L. Ward, W.R. Huckle, D. Sisson and R.L. Pyle (2006) N-terminal atrial natriuretic peptide immunoreactivity in cats with hypertrophic cardiomyopathy, J. Vet. Int. Med. 20:284-289.
  4. Paye, J.M.D., Akers, R.M., Huckle, W.R., Forsten-Williams, K. (2007) Production of insulin-like growth factor-I (IGF-I) impacts paracellular transport across epithelial cells in vitro, Cell Commun. Adhes. 14:85-98.
  5. Rossmeisl, J.H., Duncan, R.B., Huckle, W.R., Troy, G.C. (2007) Vascular endothelial growth factor expression in dogs with primary intracranial neoplasms, Am. J. Vet. Res. 68:1239–1245.
  6. Peralta, O.A., W.R. Huckle, W.H. Eyestone (2011) Expression and knockdown of cellular prion protein (PrPC) in differentiating mouse embryonic stem cells, Differentiation 81:68–77.
  7. Sandberg, C.A., I.P. Herring, W.R. Huckle, T. LeRoith, J.P.Pickett, J.H. Rossmeisl (2012) Aqueous humor vascular endothelial growth factor in dogs: Association with intraocular disease and the development of pre-iridal fibrovascular membrane, Vet. Ophthalmol. 15 Suppl 1:21-30.
  8. Peralta OA, Huckle WR, Eyestone WH. (2012) Developmental expression of the cellular prion protein (PrP(C)) in bovine embryos. Mol Reprod Dev. 79:488-498.
  9. Binder DR, Herring IP, Zimmerman KL, Pickett JP, Huckle WR. (2012) Expression of vascular endothelial growth factor receptor-1 and -2 in normal and diseased canine eyes, Vet. Ophthalmol. 15:223-230.
  10. Sa, Q., Ochaia, E., Tiwari, A., Huckle, W.R., Eyestone, W.H., Saunders, T.L., and Suzuki, Y. (2015) Cutting Edge: IFN-γ produced by brain-resident cells is crucial to control cerebral infection with Toxoplasma gondii, J Immunol. 195:796-800.