Xin M. Luo, PhD

PhD, Immunology, 2006
Pennsylvania State University
University Park, PA

MS, Nutritional Sciences, 2001
Pennsylvania State University
University Park, PA

Biochemistry and Molecular Biology, 1998
Peking University
Beijing, China

• The research interests in the Luo Laboratory are immunological and microbial regulation of autoimmunity and immunodeficiency. On the immunological side, we are interested in the roles of dendritic cells in inflammation; while on the microbial side, we focus on how commensal bacteria in the gut affect the host immune system, and vice versa. We utilize murine models and human patient samples to study various diseases including systemic lupus erythematosus and primary immunodeficiencies.

2023–present
Professor
Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

2018–2023
Associate Professor
Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

2012–2018
Assistant Professor
Department of Biomedical Sciences and Pathobiology
Virginia-Maryland College of Veterinary Medicine
Virginia Tech
Blacksburg, VA

September-December 2011
Scientist II
Cell Signaling Technology

2010–2011
Research Scientist
Division of Biology
California Institute of Technology
Pasadena, CA

2005–2010
Postdoctoral Fellow
Mentor: David Baltimore (Nobel Laureate)
Division of Biology
California Institute of Technology
Pasadena, CA

• American Association of Immunologists
• Society for Mucosal Immunology

1. Cabana-Puig X, Lu R, Geng S, Michaelis JS, Oakes V, Armstrong C, Testerman JC, Liao X, Alajoleen R, Appiah M, Zhang Y, Reilly CM, Li L, Luo XM (2023) CX₃CR1 modulates SLE-associated glomerulonephritis and cardiovascular disease in MRL/lpr mice. Inflammation Research 72(5):1083-1097.
2. Abdelhamid L, Mao J, Cabana-Puig X, Zhu J, Swartwout BK, Edwards MR, Testerman J, Michaelis JS, Allen IC, Ahmed SA, Luo XM (2023) Nlrp12 deficiency alters gut microbiota and ameliorates Fas^lpr -mediated systemic autoimmunity in male mice. Frontiers in Immunology 14:1120958.
3. Cabana-Puig X, Mu Q, Lu R, Swartwout B, Abdelhamid L, Zhu J, Prakash M, Cecere TE, Wang Z, Callaway S, Sun S, Reilly CM, Ahmed SA, Luo XM (2022) Lactobacillus spp. act in synergy to attenuate splenomegaly and lymphadenopathy in lupus-prone MRL/lpr mice. Frontiers in Immunology 13:923754.
4. Mu Q, Swartwout BK, Edwards MR, Zhu J, Lee G, Eden K, Cabana-Puig X, McDaniel DK, Mao J, Abdelhamid L, Brock RM, Allen IC, Reilly CM, Luo XM (2021) Regulation of neonatal IgA production of the maternal microbiota. Proceedings of the National Academy of Sciences 118 (9): e2015691118.
5. Mu Q, Edwards MR, Swartwout BK, Cabana-Puig X, Mao J, Zhu J, Grieco J, Cecere TE, Prakash M, Reilly CM, Puglisi C, Bachali P, Grammer AC, Lipsky PE, Luo XM (2020) Gut microbiota and bacterial DNA suppress autoimmunity by stimulating regulatory B cells in a murine model of lupus. Frontiers in Immunology 11:593353.
6. Abdelhamid L, Cabana-Puig X, Mu Q, Moarefian M, Swartwout B, Eden K, Das P, Seguin RP, Xu L, Lowen S, Lavani M, Hrubec TC, Jones CN, Luo XM (2020) Quaternary ammonium compound disinfectants reduce lupus-associated splenomegaly by targeting neutrophil migration and T-cell fate. Frontiers in Immunology 11:575179.
7. Abdelhamid L, Cabana-Puig X, Swartwout B, Lee J, Li S, Sun S, Li Y, Ross AC, Cecere TE, LeRoith T, Werre SR, Wang H, Reilly CM, Luo XM (2020) Retinoic acid exerts disease stage-dependent effects on pristane-induced lupus. Frontiers in Immunology 11:408.
8. Mu Q, Cabana-Puig X, Mao J, Swartwout B, Abdelhamid L, Cecere TE, Wang H, Reilly CM, Luo XM (2019) Pregnancy and lactation interfere with the response of autoimmunity to modulation of gut microbiota. Microbiome 7(1):105.
9. Luo XM, Edwards MR, Mu Q, Yu Y, Vieson MD, Reilly CM, Ahmed SA, Bankole AA (2018) Gut microbiota in human systemic lupus erythematosus and a mouse model of lupus. Applied and Environmental Microbiology 84(4). pii: e02288-17.
10. Mu Q, Zhang H, Liao X, Lin K, Liu H, Edwards MR, Ahmed SA, Yuan R, Li L, Cecere TE, Branson DB, Kirby JL, Goswami P, Leeth CM, Read KA, Oestreich KJ, Vieson MD, Reilly CM, Luo XM. (2017) Control of lupus nephritis by changes of gut microbiota. Microbiome 5(1): 73.